PPAP
typecatecholamine activity enhancer
pathwaysdopamine, norepinephrine
benefitsADHD/Focus, Depression, Longevity, Motivation, Wakefulness
stacks well withLisdexamfetamine
Lisdexamfetamine
typeamphetamine prodrug
pathwaysdopamine, norepinephrine
brain regionsprefrontal cortex, striatum
benefitsADHD/Focus, Motivation, Wakefulness
stacks well withGuanfacine, Bromantane, N-Acetylsemax
Dihexa
typenootropic peptide
targetsHGF receptor, MET receptor
processesLTP, neurogenesis
brain regionshippocampus
ACD-856
typeTrkB PAM
processesLTP, neurogenesis
brain regionshippocampus
benefitsDepression, Drug Cravings, Higher Cognition, Memory, Neuroplasticity
stacks well withTAK-653, glutamatergics, neurogenics
N-Acetylsemax
typenootropic peptide
targetsTrkB
pathwaysBDNF, dopamine, serotonin, norepinephrine
processesneurogenesis
benefitsADHD/Focus, Depression, Higher Cognition, Memory, Motivation, Neuroplasticity
stacks well withN Acetylselank, ACD-856, Lisdexamfetamine
Selegiline
typeMAO-B inhibitor
targetsMAO B
pathwaysdopamine, phenethylamine
brain regionsstriatum
benefitsADHD/Focus, Depression, Longevity, Motivation, Neuroplasticity, Wakefulness
Neboglamine
typeNMDA glycine PAM
targetsNMDA receptor, NR2B
brain regionshippocampus
benefitsHigher Cognition, Memory, Neuroplasticity
Guanfacine
typeα2A adrenergic agonist
targetsα2A adrenoceptor
pathwaysnorepinephrine, cAMP
brain regionsprefrontal cortex, DLPFC
benefitsADHD/Focus, Anxiety, Drug Cravings, Higher Cognition, Motivation, PFC Top-Down Control
stacks well withLisdexamfetamine
Zinc Gluconate
typemineral supplement
targetsdopamine transporter, NMDA receptor
pathwaysdopamine
benefitsADHD/Focus, Depression, General Health, Illness Prevention, Motivation, Nutritional Supplementation
stacks well withLisdexamfetamine
Bromantane
typedopaminergic
benefitsADHD/Focus, Anxiety, Depression, Memory, Motivation, Neuroplasticity, Wakefulness
stacks well withLisdexamfetamine, psychostimulants
TAK-653
typeAMPA PAM
targetsAMPA receptor, GluR2
processesLTP
brain regionsprefrontal cortex, hippocampus
benefitsADHD/Focus, Depression, Higher Cognition, Memory, Neuroplasticity
stacks well withACD-856, Neboglamine
AF710B
typeM1-Sigma1 agonist
pathwayscAMP, ERK, acetylcholine
brain regionsDLPFC, hippocampus
benefitsHigher Cognition, Memory, Neuroplasticity, Longevity
stacks well withCerebrolysin, ACD-856
Methylene Blue
typeRIMA
targetsMAO, acetylcholinesterase
pathwayscytochrome c oxidase, nitric oxide
processesmitochondrial biogenesis
benefitsADHD/Focus, Antioxidation, Bipolar, Cancer Prevention, Depression, General Health, Higher Cognition, Illness Prevention, Longevity, Memory
stacks well withSertraline, serotonergic antidepressants (WITH CAUTION)
Tropisetron
typeα7 nAChR agonist
targetsα7 nAChR, 5 HT3 receptor, SIRT1
pathwaysacetylcholine, cAMP, serotonin
processesLTP, neurogenesis
brain regionsprefrontal cortex, hippocampus
benefitsADHD/Focus, Higher Cognition, Memory, Motivation, PFC Top-Down Control
stacks well withNicotine (enhances and prolongs effects)
Usmarapride
type5-HT4 partial agonist
targets5 HT4 receptor
processesLTP, neurogenesis
brain regionshippocampus
benefitsMemory, Higher Cognition, Depression, Anxiety, Neuroplasticity
stacks well withACD-856, Tropisetron
Semax
typenootropic peptide
targetsTrkB
pathwaysBDNF, dopamine, serotonin, norepinephrine
processesneurogenesis
benefitsADHD/Focus, Anxiety, Wakefulness
BPAP
typecatecholamine activity enhancer
pathwaysdopamine, norepinephrine
benefitsADHD/Focus, Depression, Longevity, Motivation