PPAP

typecatecholamine activity enhancer

pathwaysdopamine, norepinephrine

benefitsADHD/Focus, Depression, Longevity, Motivation, Wakefulness

stacks well withLisdexamfetamine

Lisdexamfetamine

typeamphetamine prodrug

targetsdopamine transporter, norepinephrine transporter

pathwaysdopamine, norepinephrine

brain regionsprefrontal cortex, striatum

benefitsADHD/Focus, Motivation, Wakefulness

stacks well withGuanfacine, Bromantane, N-Acetylsemax

Dihexa

typenootropic peptide

targetsHGF receptor, MET receptor

pathwaysBDNF, NGF

processesLTP, neurogenesis

brain regionshippocampus

ACD-856

typeTrkB PAM

targetsTrkB, TrkA, TrkC

pathwaysBDNF, NGF

processesLTP, neurogenesis

brain regionshippocampus

benefitsDepression, Drug Cravings, Higher Cognition, Memory, Neuroplasticity

stacks well withTAK-653, glutamatergics, neurogenics

N-Acetylsemax

typenootropic peptide

targetsTrkB

pathwaysBDNF, dopamine, serotonin, norepinephrine

processesneurogenesis

benefitsADHD/Focus, Depression, Higher Cognition, Memory, Motivation, Neuroplasticity

stacks well withN Acetylselank, ACD-856, Lisdexamfetamine

Selegiline

typeMAO-B inhibitor

targetsMAO B

pathwaysdopamine, phenethylamine

brain regionsstriatum

benefitsADHD/Focus, Depression, Longevity, Motivation, Neuroplasticity, Wakefulness

Neboglamine

typeNMDA glycine PAM

targetsNMDA receptor, NR2B

pathwaysD Serine, BDNF

processesLTP, LTD

brain regionshippocampus

benefitsHigher Cognition, Memory, Neuroplasticity

stacks well withTAK-653, ACD-856

Guanfacine

typeα2A adrenergic agonist

targetsα2A adrenoceptor

pathwaysnorepinephrine, cAMP

brain regionsprefrontal cortex, DLPFC

benefitsADHD/Focus, Anxiety, Drug Cravings, Higher Cognition, Motivation, PFC Top-Down Control

stacks well withLisdexamfetamine

Zinc Gluconate

typemineral supplement

targetsdopamine transporter, NMDA receptor

pathwaysdopamine

benefitsADHD/Focus, Depression, General Health, Illness Prevention, Motivation, Nutritional Supplementation

stacks well withLisdexamfetamine

Bromantane

typedopaminergic

targetsdopamine transporter, serotonin transporter

pathwaysdopamine, serotonin, BDNF

benefitsADHD/Focus, Anxiety, Depression, Memory, Motivation, Neuroplasticity, Wakefulness

stacks well withLisdexamfetamine, psychostimulants

TAK-653

typeAMPA PAM

targetsAMPA Receptor, GluR2

pathwaysmTOR, BDNF, ERK

processesLTP

brain regionsprefrontal cortex, hippocampus

benefitsADHD/Focus, Depression, Higher Cognition, Memory, Neuroplasticity

stacks well withACD-856, Neboglamine

AF710B

typeM1-Sigma1 agonist

targetsM1 muscarinic receptor, Sigma 1 receptor

pathwayscAMP, ERK, Acetylcholine

processesLTP, LTD

brain regionsDLPFC, hippocampus

benefitsHigher Cognition, Memory, Neuroplasticity, Longevity

stacks well withCerebrolysin, ACD-856

Methylene Blue

typeRIMA

targetsMAO, acetylcholinesterase

pathwayscytochrome c oxidase, nitric oxide

processesmitochondrial biogenesis

benefitsADHD/Focus, Antioxidation, Bipolar, Cancer Prevention, Depression, General Health, Higher Cognition, Illness Prevention, Longevity, Memory

stacks well withSertraline, serotonergic antidepressants (WITH CAUTION)

Tropisetron

typeα7 nAChR agonist

targetsα7 nAChR, 5 HT3 receptor, SIRT1

pathwaysAcetylcholine, cAMP, serotonin

processesLTP, neurogenesis

brain regionsprefrontal cortex, hippocampus

benefitsADHD/Focus, Higher Cognition, Memory, Motivation, PFC Top-Down Control

stacks well withNicotine (enhances and prolongs effects)

Usmarapride

type5-HT4 partial agonist

targets5 HT4 receptor

pathwayscAMP, BDNF, serotonin

processesLTP, neurogenesis

brain regionshippocampus

benefitsMemory, Higher Cognition, Depression, Anxiety, Neuroplasticity

stacks well withACD-856, Tropisetron

Semax

typenootropic peptide

targetsTrkB

pathwaysBDNF, dopamine, serotonin, norepinephrine

processesneurogenesis

benefitsADHD/Focus, Anxiety, Wakefulness

BPAP

typecatecholamine activity enhancer

pathwaysdopamine, norepinephrine

benefitsADHD/Focus, Depression, Longevity, Motivation

ABT-089

typeα4β2 nAChR partial agonist

targetsα4β2 nicotinic receptor

pathwaysAcetylcholine

processesattentional filtering, working memory

brain regionsprefrontal cortex, thalamus

benefitsAttention, Working memory, Cognitive filtering

stacks well withTropisetron

BPN14770

typePDE4D inhibitor

targetsPDE4D

pathwayscAMP, PKA, CREB, BDNF

processesLTP, synaptic consolidation

brain regionshippocampus, prefrontal cortex

benefitsMemory consolidation, LTP, Neuroplasticity

stacks well withACD-856

Fasoracetam

typemGluR2/3 agonist / GABA-B upregulator

targetsmGluR2, mGluR3, GABA B receptor

pathwaysGlutamate, GABA

processesreceptor resensitization, I balance

brain regionsprefrontal cortex, hippocampus

benefitsReceptor resensitization, E/I balance restoration, Anxiolytic

stacks well withTUDCA, AF710B

KW-6356

typeA2A adenosine receptor antagonist

targetsA2A adenosine receptor, D2 receptor

pathwaysdopamine, adenosine, cAMP

processesdopaminergic signaling

brain regionsstriatum, basal ganglia

benefitsMotivation, Drive, Goal-directed behavior

stacks well withBromantane

Tabernanthalog

typeTrkB partial agonist / 5-HT2A partial agonist

targetsTrkB, 5 HT2A receptor

pathwaysBDNF, serotonin

processessynaptogenesis, dendritic growth

brain regionshippocampus, prefrontal cortex

benefitsDendritic growth, Synaptogenesis, Neural repair, Neuroplasticity

stacks well withCerebrolysin