PPAP

typecatecholamine activity enhancer

pathwaysdopamine, norepinephrine

benefitsADHD/Focus, Depression, Longevity, Motivation, Wakefulness

stacks well withLisdexamfetamine

namePPAP.md

Lisdexamfetamine

typeamphetamine prodrug

targetsdopamine transporter, norepinephrine transporter

pathwaysdopamine, norepinephrine

brain regionsprefrontal cortex, striatum

benefitsADHD/Focus, Motivation, Wakefulness

stacks well withGuanfacine, Bromantane, N-Acetylsemax

nameLisdexamfetamine.md

Dihexa

typenootropic peptide

targetsHGF receptor, MET receptor

pathwaysBDNF, NGF

processesLTP, neurogenesis

brain regionshippocampus

nameDihexa.md

ACD-856

typeTrkB PAM

targetsTrkB, TrkA, TrkC

pathwaysBDNF, NGF

processesLTP, neurogenesis

brain regionshippocampus

benefitsDepression, Drug Cravings, Higher Cognition, Memory, Neuroplasticity

stacks well withTAK-653, glutamatergics, neurogenics

nameACD-856.md

N-Acetylsemax

typenootropic peptide

targetsTrkB

pathwaysBDNF, dopamine, serotonin, norepinephrine

processesneurogenesis

benefitsADHD/Focus, Depression, Higher Cognition, Memory, Motivation, Neuroplasticity

stacks well withN Acetylselank, ACD-856, Lisdexamfetamine

nameN-Acetylsemax.md

Selegiline

typeMAO-B inhibitor

targetsMAO B

pathwaysdopamine, phenethylamine

brain regionsstriatum

benefitsADHD/Focus, Depression, Longevity, Motivation, Neuroplasticity, Wakefulness

nameSelegiline.md

Neboglamine

typeNMDA glycine PAM

targetsNMDA receptor, NR2B

pathwaysD Serine, BDNF

processesLTP, LTD

brain regionshippocampus

benefitsHigher Cognition, Memory, Neuroplasticity

stacks well withTAK-653, ACD-856

nameNeboglamine.md

Guanfacine

typeα2A adrenergic agonist

targetsα2A adrenoceptor

pathwaysnorepinephrine, cAMP

brain regionsprefrontal cortex, DLPFC

benefitsADHD/Focus, Anxiety, Drug Cravings, Higher Cognition, Motivation, PFC Top-Down Control

stacks well withLisdexamfetamine

nameGuanfacine.md

Zinc Gluconate

typemineral supplement

targetsdopamine transporter, NMDA receptor

pathwaysdopamine

benefitsADHD/Focus, Depression, General Health, Illness Prevention, Motivation, Nutritional Supplementation

stacks well withLisdexamfetamine

nameZinc Gluconate.md

Bromantane

typedopaminergic

targetsdopamine transporter, serotonin transporter

pathwaysdopamine, serotonin, BDNF

benefitsADHD/Focus, Anxiety, Depression, Memory, Motivation, Neuroplasticity, Wakefulness

stacks well withLisdexamfetamine, psychostimulants

nameBromantane.md

TAK-653

typeAMPA PAM

targetsAMPA receptor, GluR2

pathwaysmTOR, BDNF, ERK

processesLTP

brain regionsprefrontal cortex, hippocampus

benefitsADHD/Focus, Depression, Higher Cognition, Memory, Neuroplasticity

stacks well withACD-856, Neboglamine

nameTAK-653.md

AF710B

typeM1-Sigma1 agonist

targetsM1 muscarinic receptor, Sigma 1 receptor

pathwayscAMP, ERK, acetylcholine

processesLTP, LTD

brain regionsDLPFC, hippocampus

benefitsHigher Cognition, Memory, Neuroplasticity, Longevity

stacks well withCerebrolysin, ACD-856

nameAF710B.md

Methylene Blue

typeRIMA

targetsMAO, acetylcholinesterase

pathwayscytochrome c oxidase, nitric oxide

processesmitochondrial biogenesis

benefitsADHD/Focus, Antioxidation, Bipolar, Cancer Prevention, Depression, General Health, Higher Cognition, Illness Prevention, Longevity, Memory

stacks well withSertraline, serotonergic antidepressants (WITH CAUTION)

nameMethylene Blue.md

Tropisetron

typeα7 nAChR agonist

targetsα7 nAChR, 5 HT3 receptor, SIRT1

pathwaysacetylcholine, cAMP, serotonin

processesLTP, neurogenesis

brain regionsprefrontal cortex, hippocampus

benefitsADHD/Focus, Higher Cognition, Memory, Motivation, PFC Top-Down Control

stacks well withNicotine (enhances and prolongs effects)

nameTropisetron.md

Usmarapride

type5-HT4 partial agonist

targets5 HT4 receptor

pathwayscAMP, BDNF, serotonin

processesLTP, neurogenesis

brain regionshippocampus

benefitsMemory, Higher Cognition, Depression, Anxiety, Neuroplasticity

stacks well withACD-856, Tropisetron

nameUsmarapride.md

Semax

typenootropic peptide

targetsTrkB

pathwaysBDNF, dopamine, serotonin, norepinephrine

processesneurogenesis

benefitsADHD/Focus, Anxiety, Wakefulness

nameSemax.md

BPAP

typecatecholamine activity enhancer

pathwaysdopamine, norepinephrine

benefitsADHD/Focus, Depression, Longevity, Motivation

nameBPAP.md

ABT-089

typeα4β2 nAChR partial agonist

targetsα4β2 nicotinic receptor

pathwaysacetylcholine

processesattentional filtering, working memory

brain regionsprefrontal cortex, thalamus

benefitsAttention, Working memory, Cognitive filtering

stacks well withTropisetron

nameABT-089.md

BPN14770

typePDE4D inhibitor

targetsPDE4D

pathwayscAMP, PKA, CREB, BDNF

processesLTP, synaptic consolidation

brain regionshippocampus, prefrontal cortex

benefitsMemory consolidation, LTP, Neuroplasticity

stacks well withACD-856

nameBPN14770.md

Fasoracetam

typemGluR2/3 agonist / GABA-B upregulator

targetsmGluR2, mGluR3, GABA B receptor

pathwaysGlutamate, GABA

processesreceptor resensitization, I balance

brain regionsprefrontal cortex, hippocampus

benefitsReceptor resensitization, E/I balance restoration, Anxiolytic

stacks well withTUDCA, AF710B

nameFasoracetam.md

KW-6356

typeA2A adenosine receptor antagonist

targetsA2A adenosine receptor, D2 receptor

pathwaysdopamine, adenosine, cAMP

processesdopaminergic signaling

brain regionsstriatum, basal ganglia

benefitsMotivation, Drive, Goal-directed behavior

stacks well withBromantane

nameKW-6356.md

Tabernanthalog

typeTrkB partial agonist / 5-HT2A partial agonist

targetsTrkB, 5 HT2A receptor

pathwaysBDNF, serotonin

processessynaptogenesis, dendritic growth

brain regionshippocampus, prefrontal cortex

benefitsDendritic growth, Synaptogenesis, Neural repair, Neuroplasticity

stacks well withCerebrolysin

nameTabernanthalog.md